Introduction: Pediatric ontological emergencies are critical clinical conditions that arise due to structural or metabolic changes caused by cancer or its treatment, requiring immediate intervention to prevent loss of life or improve quality of life. The emergency department is often the first point of contact for newly diagnosed pediatric oncology patients, who may be severely ill at presentation. Common pediatric oenological emergencies include Tumor Lyses Syndrome, Superior Vena Cava Syndrome, and Spinal Cord Compression. This study aimed to review these emergencies in critical care settings and identify key management strategies to support ICU nursing staff. Methods: A quantitative research approach with a descriptive research design was adopted. The study was conducted among 30 staff nurses at Sri Manakula Vinayagar Nursing College, Pondicherry. 

A structured questionnaire was used to assess their knowledge regarding selected pediatric oenological emergencies. The study also examined the association between the nurse’s level of knowledge and selected demographic variables. Results: The findings revealed that 44% of participants had inadequate knowledge, while 16% demonstrated moderate knowledge regarding pediatric oenological emergencies. 

These results indicate that while some nurses have foundational knowledge and clinical exposure, there is a significant gap in comprehensive understanding and preparedness for managing such emergencies. Discussion: The study highlights the need for targeted educational interventions to enhance nurse’s knowledge and confidence in managing pediatric oenological emergencies. Recognizing early signs, even before changes in vital signs occur, is critical in improving patient outcomes. Continued training and clinical experience can help ICU nurses respond more effectively to these life-threatening situations.