Memory is the mind’s ability to encode, retain, and retrieve information—an indispensable foundation for learning. Memory plays a vital role in the academic and professional life of nursing students. However, one of the most commonly cited challenges among students is the difficulty in retaining large amounts of academic material, primarily due to a lack of formal training in effective memory and recall strategies. This quasi-experimental study evaluated the impact of Memory Enhancement Techniques (METs), particularly mnemonics, on memory retention among 60 first-semester B.Sc. nursing students in Bangalore. Memory retention was assessed using the Multi factorial Memory Questionnaire before and after administering a structured mnemonic exercise. Initially, only 10% of students demonstrated good memory strategies, while 47% showed poor strategies. After the intervention, 62% exhibited good memory strategies, and only 2% had poor strategies. Statistical analysis revealed a significant improvement in memory retention post-intervention (p = 0.000). These results suggest that mnemonics are an effective method for enhancing memory retention in nursing students. The study highlights the importance of incorporating METs into nursing education to improve students’ academic performance and learning outcomes.